業績一覧
- Bai Y, Morita K, Kokaji T, Hatano A, Ohno S, Egami R, Pan Y, Li D, Yugi K, Uematsu S, Inoue H, Inaba Y, Suzuki Y, Matsumoto M, Takahashi M, Izumi Y, Bamba T, Hirayama A, Soga T, Kuroda S. Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity. iScience. 2024 Feb 26;27(3):109121.
- Qiu Y, Sajidah ES, Kondo S, Narimatsu S, Sandira MI, Higashiguchi Y, Nishide G, Taoka A, Hazawa M, Inaba Y, Inoue H, Matsushima A, Okada Y, Nakada M, Ando T, Lim K, Wong RW. An Efficient Method for Isolating and Purifying Nuclei from Mice Brain for Single-Molecule Imaging Using High-Speed Atomic Force Microscopy. Cells. 2024 Feb 2;13(3):279.
2023
- Matsukawa T, Yagi T, Uchida T, Sakai M, Mitsushima M, Naganuma T, Yano H, Inaba Y, Inoue H, Yanagida K, Uematsu M, Nakao K, Nakao H, Aiba A, Nagashima Y, Kubota T, Kubota N, Izumida Y, Yahagi N, Unoki-Kubota H, Kaburagi Y, Asahara SI, Kido Y, Shindou H, Itoh M, Ogawa Y, Minami S, Terauchi Y, Tobe K, Ueki K, Kasuga M, Matsumoto M. Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models.
JCI Insight. 2023 Sep 8;8(17):e161282.
- Park G, Fukasawa K, Horie T, Masuo Y, Inaba Y, Tatsuno T, Yamada T, Tokumura K, Iwahashi S, Iezaki T, Kaneda K, Kato Y, Ishigaki Y, Mieda M, Tanaka T, Ogawa K, Ochi H, Sato S, Shi YB, Inoue H, Lee H, Hinoi E. L-type amino acid transporter 1 in hypothalamic neurons in mice maintains energy and bone homeostasis.
JCI Insight. 2023 Apr 10;8(7):e154925.
- Inaba Y, Hashiuchi E, Watanabe H, Kimura K, Oshima Y, Tsuchiya K, Murai S, Takahashi C, Matsumoto M, Kitajima S, Yamamoto Y, Honda M, Asahara S, Ravnskjaer K, Horike S, Kaneko S, Kasuga M, Nakano H, Harada K, Inoue H*. The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice.
Nat Commun. 2023 Jan 23;14(1):167.
2022
- Kokaji T, Eto M, Hatano A, Yugi K, Morita K, Ohno S, Fujii M, Hironaka KI, Ito Y, Egami R, Uematsu S, Terakawa A, Pan Y, Maehara H, Li D, Bai Y, Tsuchiya T, Ozaki H, Inoue H, Kubota H, Suzuki Y, Hirayama A, Soga T, Kuroda S. In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states.
Sci Rep. 2022 Aug 12;12(1):13719.
- Fujita S, Karasawa Y, Fujii M, Hironaka KI, Uda S, Kubota H, Inoue H, Sumitomo Y, Hirayama A, Soga T, Kuroda S*. Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans.
NPJ Syst Biol Appl. 2022 Feb;8(1):6.
2021
- Sheng J, Kohno S, Okada N, Okahashi N, Teranishi K, Matsuda F, Shimizu H, Linn P, Nagatani N, Yamamura M, Harada K, Horike SI, Inoue H, Yano S, Kumar S, Kitajima S, Ajioka I, Takahashi C*. Treatment of RB1-intact hepatocellular carcinoma with CDK4/6 inhibitor combination therapy.
Hepatology. 2021 Oct;74(4):1971-1993.
- Egami R, Kokaji T, Hatano A, Yugi K, Eto M, Morita K, Ohno S, Fujii M, Hironaka KI, Uematsu S, Terakawa A, Bai Y, Pan Y, Tsuchiya T, Ozaki H, Inoue H, Uda S, Kubota H, Suzuki Y, Matsumoto M, Nakayama KI, Hirayama A, Soga T, Kuroda S*. Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle.
iScience. 2021 Feb;24(3):102217.
- Tateishi R*, Matsumura T, Okanoue T, Shima T, Uchino K, Fujiwara N, Senokuchi T, Kon K, Sasako T, Taniai M, Kawaguchi T, Inoue H, Watada H, Kubota N, Shimano H, Kaneko S, Hashimoto E, Watanabe S, Shiota G, Ueki K, Kashiwabara K, Matsuyama Y, Tanaka H, Kasuga M, Araki E, Koike K. LUCID study investigators. Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan.
J Gastroenterol. 2021 Mar;56(3):261-273.
- Hashiuchi E, Watanabe H, Kimura K, Matsumoto M, Inoue H, Inaba Y*.
Diet Intake Control Is Indispensable for the Gluconeogenic Response to Sodium-Glucose Cotransporter 2 Inhibition in Male Mice.
J Diabetes Investig. 2021 Jan;12(1):35-47.
2020
- Kokaji T, Hatano A, Ito Y, Yugi K, Eto M, Ohno S, Fujii M, Hironaka K, Egami R, Inoue H, Uda S, Kubota H, Suzuki Y, Ikeda K, Arita M, Matsumoto M, Nakayama KI, Ohishi M, Ueno A, Endo K, Hirayama A, Soga T, Kuroda S*.
Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity.
Sci Signal. 2020 Dec 1;13(660):eaaz1236.
- Matsumoto A, Kuwata H, Kimura S, Matsumoto H, Ochi K, Moro-Oka Y, Watanabe A, Yamada H, Ishii H, Miyazawa T, Chen S, Baba T, Yoshida H, Nakamura T, Inoue H, Ogawa Y, Tanaka M, Miyahara Y, Suganami T*.
Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system.
Commun Biol. 2020 Jun 17;3(1):313.
- Kanno A, Asahara SI, Furubayashi A, Masuda K, Yoshitomi R, Suzuki E, Takai T, Kimura-Koyanagi M, Matsuda T, Bartolome A, Hirota Y, Yokoi N, Inaba Y, Inoue H, Matsumoto M, Inoue K, Abe T, Wei FY, Tomizawa K, Ogawa W, Seino S, Kasuga M, Kido Y*.
GCN2 regulates pancreatic β-cell mass by sensing intracellular amino acid levels.
JCI Insight. 2020 May 7;5(9): pii:128820.
2019
- Inaba Y*#, Hashiuchi E#, Watanabe H, Kimura K, Sato M, Kobayashi M, Matsumoto M, Kitamura T, kasuga M, Inoue H*.
Hepatic gluconeogenic response to single and long-term SGLT2 inhibition in lean/obese male hepatic G6pc-reporter mice.
Endocrinology. 2019 Dec 1;160(12):2811-2824. (# ; contributed equally)
- Horie T, Park G, Inaba Y, Hashiuchi E, Iezaki T, Tokumura K, Fukasawa K, Yamada T, HiraiwaM, Kitaguchi Y, Kamada H, Kaneda K, Tanaka T, Inoue H, Hinoi E*.
MAPK Erk5 in leptin receptor-expressing neurons controls body weight and systemic energy homeostasis in female mice.
Endocrinology. 2019 Dec 1;160(12):2837-2848.
- Fujii M, Murakami Y, Karasawa Y, Sumitomo Y, Fujita S, Koyama M, Uda S, Kubota H, Inoue H, Konishi K, Oba S, Ishii S, Kuroda S*.
Logical design of oral glucose ingestion pattern minimizing blood glucose in humans.
npj Systems Biology and Applications. 2019 Sep 2;5:31.
- Kimura K, Inaba Y*, Watanabe H, Matsukawa T, Matsumoto M, Inoue H*.
Nicotinic alpha 7 acetylcholine receptor deficiency exacerbates hepatic inflammation and fibrosis in a mouse model of non-alcoholic steatohepatitis.
J Diabetes Investig. 2019 May;10(3):659-666.
2018
- Yano H, Sakai M, Matsukawa T, Yagi T, Naganuma T, Mitsushima M, Iida S, Inaba Y, Inoue H, Unoki-Kubota H, Kaburagi Y, Asahara S, Kido Y, Minami S, Kasuga M, Matsumoto M*.
PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes.
Sci Rep. 2018 Sep 24;8(1):14290.
- Watanabe K, Igarashi M, Li X, Nakatani A, Miyamoto J, Inaba Y, Sutou A, Saito T, Sato T, Tachibana N, Inoue H, Kimura I*.
Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids.
PLoS One. 2018 Aug 13;13(8):e0202083.
- Nakatani A, Li X, Miyamoto J, Igarashi J, Watanabe H, Sutou A, Watanabe K, Motoyama T, Tachibana N, Kohno M, Inoue H, Kimura I*.
Dietary mung bean protein reduces high-fat diet-induced weight gain by modulating host bile acid metabolism in a gut microbiota-dependent manner.
Biochem Biophys Res Commun. 2018 Jul 2;501(4):955-961.
- Watanabe H, Inaba Y, Kimura K, Kaneko S, Matsumoto M, Kasuga M, Inoue H*.
Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein.
Nat Commun. 2018 Jan 2;9(1):30.
2017
- Onogi Y, Wada T, Kamiya C, Inata K, Matsuzawa T, Inaba Y, Kimura K, Inoue H, Yamamoto S, Ishii Y, Koya D, Tsuneki H, Sasahara M, Sasaoka T*.
PDGFRβ regulates adipose tissue expansion and glucose metabolism via vascular remodeling in diet-induced obesity.
Diabetes. 2017 Apr;66(4):1008-1021.
- Watanabe H, Inaba Y, Kimura K, Asahara S, Kido Y, Matsumoto M, Motoyama T, Tachibana N, Kaneko S, Kohno M, Inoue H*.
Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-induced, Non-alcoholic Fatty Liver Disease.
J Nutr. 2017 Apr;66(4):1008-1021.
2016
- Sakai M, Tsujimura T, Yagi T, Yano H, Mitsushima M, Unoki-Kubota H, Kaburagi Y, Inoue H, Kido Y, Kasuga M, Matsumoto M*.
The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch.
Nat Commun. 2016 Nov 22;7:13147.
- Morimoto M, Lee EY, Zhang X, Inaba Y, Inoue H, Ogawa M, Shirasawa T, Yokosuka O, Miki T*.
Eicosapentaenoic acid ameliorates hyperglycemia in high-fat diet-sensitive diabetes mice in conjunction with restoration of hypoadiponectinemia.
Nutr Diabetes. 2016 Jun 27;6:e213.
- Kimura K#, Tanida M#, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H*.
Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor.
Cell Rep. 2016 Mar 15;14(10):2362-74. (# ; contributed equally)
- Kobayashi K, Tanaka T, Okada S, Morimoto Y, Matsumura S, Manio MC, Inoue K, Kimura K, Yagi T, Saito Y, Fushiki T, Inoue H, Matsumoto M, Nabeshima Y*.
Hepatocyte β-Klotho regulates lipid homeostasis but not body weight in mice.
FASEB J. 2016 Feb;30(2):849-62.
- REVIEW; Inoue H. Central insulin-mediated regulation
of hepatic glucose production.
Endocrine J. 2016
Jan:63(1):1-7.
2015
- Asahara S, Etoh H, Inoue H, Teruyama K, Shibutani Y, Ihara Y, Kawada Y,
Bartolome A, Hashimoto N, Matsuda T, Koyanagi-Kimura M, Kanno A, Hirota
Y, Hosooka T, Nagashima K, Nishimura W, Inoue H,
Matsumoto M, Higgins MJ, Yasuda K, Inagaki N, Seino S, Kasuga M, Kido Y*.
Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell
mass by epigenetic modification of Cdkn1c.
Proc Natl Acad Sci U S A. 2015
Jul 7;112(27):8332-7.
- Matsuda T, Takahashi H, Mieda Y, Shimizu S, Kawamoto T, Matsuura Y, Takai
T, Suzuki E, Kanno A, Koyanagi-Kimura M, Asahara S, Bartolome A, Yokoi
N, Inoue H, Ogawa W, Seino S, Kido Y*. Regulation
of Pancreatic β Cell Mass by Cross-Interaction between CCAAT Enhancer Binding
Protein β Induced by Endoplasmic Reticulum Stress and AMP-Activated Protein
Kinase Activity.
PLoS One. 2015 Jun 19;10(6):e0130757
- Inaba Y, Furutani T, Kimura K, Watanabe H, Haga S, Kido Y,
Matsumoto M, Yamamoto Y, Harada K, Kaneko S, Oyadomari S, Ozaki M, Kasuga
M, Inoue H*. Gadd34 regulates liver regeneration in hepatic steatosis.
Hepatology. 2015 Apr;61(4):1343-56.
- Tsuneki H, Tokai E, Nakamura Y, Takahashi K, Fujita M, Asaoka T, Kon K,
Anzawa Y, Wada T, Takasaki I, Kimura K, Inoue H, Yanagisawa M, Sakurai T, Sasaoka T*. Hypothalamic orexin
prevents hepatic insulin resistance via daily bidirectional regulation
of autonomic nervous system in mice.
Diabetes. 2015 Feb;64(2):459-70.
2014
- Haga S, Ozawa T, Yamada Y, Morita N, Nagashima I, Inoue H, Inaba Y, Noda N, Abe R, Umezawa K, Ozaki M*. p62/SQSTM1 plays a
protective role in oxidative injury of steatotic liver in a mouse hepatectomy model.
Antioxid Redox Signal. 2014 Dec 20;21(18):2515-30.
- REVIEW; Inoue H. Molecular basis of brain-mediated
regulation of hepatic glucose metabolism.
Diabetol Int. 2014;5:158-164.
- Tanaka M, Ikeda K, Suganami T*, Komiya C, Ochi K, Shirakawa I, Hamaguchi
M, Nishimura S, Manabe I, Matsuda T, Kimura K, Inoue H, Inagaki Y, Aoe S, Yamasaki S, and Ogawa Y*. Macrophage-inducible
C-type lectin underlies obesity-induced adipose tissue fibrosis.
Nat Commun. 2014;5:4982.
- Harada K, Kakuda Y, Sato Y, Ikeda H, Shimoda S, Yamamoto Y, Inoue H,
Ohta H, Kasashima S, Kawashima A, Nakanuma Y*. Alteration of energy metabolism
in the pathogenesis of bile duct lesions in primary biliary cirrhosis.
J Clin Pathol. 2014 May;67(5):396-402.
- Park JK, Jang H, Hwang S, Kim EJ, Kim DE, Oh KB, Kwon DJ, Koh JT, Kimura K, Inoue H, Jang WG, Lee JW*. ER
stress-inducible ATF3 suppresses BMP2-induced ALP expression and activation
in MC3T3-E1 cells.
Biochem Biophys Res Commun. 2014 Jan 3;443(1):333-8.
2013
- Kimura K, Nakamura Y, Inaba Y, Matsumoto M, Kido Y, Asahara S, Matsuda T, Watanabe H,
Maeda A, Inagaki F, Mukai C, Takeda K, Akira S, Ota T, Nakabayashi H, Kaneko
S, Kasuga M, Inoue H*. Histidine augments the
suppression of hepatic glucose production by central insulin action.
Diabetes. 2013 Jul;62(7):2266-77.
- Kimura I*, Ozawa K, Inoue D, Imamura T, Kimura K,
Maeda T, Terasawa K, Kashihara D, Hirano K, Tani T, Takahashi T, Miyauchi
S, Shioi G, Inoue H, Tsujimoto G. The gut microbiota
suppresses insulin-mediated fat accumulation via the short-chain fatty
acid receptor GPR43.
Nat Commun. 2013;4:1829.
- Lee YS, Sasaki T, Kobayashi M, Kikuchi O, Kim HJ, Yokota-Hashimoto H,
Shimpuku M, Susanti VY, Ido-Kitamura Y, Kimura K, Inoue H, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Ohya S, Tanaka
Y, Kitajima S, Kitamura T*. Hypothalamic ATF3 is involved in regulating
glucose and energy metabolism in mice.
Diabetologia. 2013
Jun;56(5):1383-93.
- Asahara S, Shibutani Y, Teruyama K, Inoue HY, Kawada Y, Etoh H, Matsuda
T, Kimura-Koyanagi M, Hashimoto N, Sakahara M, Fujimoto W, Takahashi H,
Ueda S, Hosooka T, Satoh T, Inoue H, Matsumoto
M, Aiba A, Kasuga M, Kido Y*. Ras-related C3 botulinum toxin substrate 1
(RAC1) regulates glucose-stimulated insulin secretion via modulation of
F-actin.
Diabetologia. 2013 May;56(5):1088-97.
2012
- Kitade H, Sawamoto K, Nagashimada M, Inoue H,
Yamamoto Y, Sai Y, Takamura T, Yamamoto H, Miyamoto KI, Ginsberg HN, Mukaida
N, Kaneko S, Ota T*. CCR5 Plays a Critical Role in Obesity-Induced Adipose
Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage
Recruitment and M1/M2 Status.
Diabetes. 2012 Jul;61(7):1680-90.
- Sakai M, Matsumoto M*, Tujimura T, Yongheng C, Noguchi T, Inagaki K, Inoue H, Hosooka T, Takazawa K, Kido Y, Yasuda K, Hiramatsu R,
Matsuki Y, Kasuga M*. CITED2 links hormonal signaling to PGC-1α acetylation
in the regulation of gluconeogenesis.
Nat Med. 2012 Mar;18(4):612-7.
- Kimura K, Yamada T,
Matusmoto M, Kido Y, Hosooka T, Asahara S, Matsuda T, Ota T, Watanabe H,
Sai Y, Miyamoto K, Kaneko S, Kasuga M, Inoue H*.
Endoplasmic Reticulum Stress Inhibits STAT3-dependent Suppression of Hepatic
Gluconeogenesis via Dephosphorylation and Deacetylation.
Diabetes. 2012 Jan;61(1):61-73.
2011
- REVIEW; Inoue H. Regulation of glucose metabolism
by central insulin action.
Biomedical Reviews. 2011; 22:31-39..
- Koyanagi M, Asahara S, Matsuda T, Hashimoto N, Shigeyama Y, Shibutani
Y, Kanno A, Fuchita M, Mikami T, Hosooka T, Inoue H,
Matsumoto M, Koike M, Uchiyama Y, Noda T, Seino S, Kasuga M, Kido Y*. Ablation
of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria
through Activation of mTORC1.
PLoS One. 2011;6(8):e23238.
2010
- Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo
X, Berdeaux R, Kim JH, Goode J, Igata M, Paz JC, Hogan MF, Singh PK, Goebel
N, Vera L, Miller N, Cui J, Jones MR, CHARGE Consortium, GIANT Consortium,
Chen YI, Taylor KD, Hsueh WA, Rotter JI, Montminy M*. The CREB Coactivator
CRTC3 Links Catecholamine Signaling to Energy Balance.
Nature.
2010 Dec 16; 468(7326):933-9.
- Takashima M, Ogawa W*, Hayashi K, Inoue H, Kinoshita
S, Okamoto Y, Sakaue H, Wataoka Y, Emi A, Senga Y, Matsuki Y, Watanabe
E, Hiramatsu R, Kasuga M. Role of KLF15 in regulation of hepatic gluconeogenesis
and metformin action.
Diabetes. 2010 Jul;59(7):1608-15.
- Wang Y, Inoue H, Ravnskjaer K, Viste K, Miller
N, Liu Y, Hedrick S, Vera L, Montminy M*. Targeted disruption of the CREB
coactivator Crtc2 increases insulin sensitivity.
Proc Natl Acad Sci USA.
2010 Feb 16;107(7):3087-92.
- Matsuda T, Kido Y*, Asahara SI, Kaisho T, Tanaka T, Hashimoto N, Shigeyama
Y, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Hosooka T, Matsumoto M, Inoue H, Uchida T, Koike M, Uchiyama Y, Akira S, Kasuga M. Ablation
of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through
the GRP78 chaperone in mice.
J Clin Invest. 2010
Jan 4;120(1):115-26.
2009
- Oka M*, Sakaguchi M, Okada T, Nagai H, Ozaki M, Yoshioka T, Inoue H,
Mukaida N, Kikkawa U, Nishigori C. Signal transducer and activator of transcription
3 upregulates interleukin-8 expression at the level of transcription in
human melanoma cells.
Exp Dermatol. 2009 Sep 16.
- Haga S, Ozaki M*, Inoue H, Okamoto Y, Ogawa W,
Takeda K, Akira S, Todo S. The survival pathways phosphatidylinositol-3
kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate
liver regeneration through hepatocyte size rather than proliferation.
Hepatology. 2009 Jan;49(1):204-14.
- Nakamichi S, Senga Y, Inoue H, Emi A, Matsuki
Y, Watanabe E, Hiramatsu R, Ogawa W*, Kasuga M. Role of the E3 ubiquitin
ligase GRAIL in glucose and lipid metabolism in the liver.
J Mol Endocrinol.
2009 Feb;42(2):161-9.
2008
- Altarejos JY, Conkright MD, Goebel N, Inoue H,
Xie X, Arias CM, Sawchenko PE, Montminy M*. The CREB Coactivator TORC1 is
Required for Energy Balance and Fertility.
Nat Med.
2008 Oct;14(10):1112-7.
- Hosooka T, Noguchi T, Kotani K, Nakamura T, Sakaue H, Inoue H,
Ogawa W, Tobimatsu K, Takazawa K, Sakai M, Matsuki Y, Hiramatsu R, Yasuda
T, Lazar MA, Yamanashi Y, Kasuga M*. Dok1 mediates high-fat diet-induced
adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation.
Nat Med. 2008 Feb;14(2):188-93.
- Zhang HQ, Haga S, Fukai M, Oikawa Y, Inoue H,
Ogawa W, Kano A, Maruyama A, Fu XY, Todo S, Enosawa S, Ozaki M*. Identification
of de novo STAT3 target gene in liver regeneration.
Hepatol Res.
2008 Apr;38(4):374-84.
2007
- Okamoto Y, Ogawa W*, Nishizawa A, Inoue H, Teshigawara
K, Kinoshita S, Matsuki Y, Watanabe E, Hiramatsu R, Sakaue H, Noda T, Kasuga
M. Restoration of glucokinase expression in the liver normalizes postprandial
glucose disposal in mice with hepatic deficiency of PDK1.
Diabetes.
2007 Apr;56(4):1000-9.
2006
- Inoue H, Ogawa W, Asakawa A, Okamoto Y, Nishizawa
A, Matsumoto M, Teshigawara K, Matsuki Y, Watanabe E, Hiramatsu R, Notohara
K, Katayose K, Okamura H, Kahn CR, Noda T, Takeda K, Akira S, Inui A, Kasuga
M*. Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.
Cell Metab. 2006 Apr;3(4):267-75.
2005
- Haga S, Ogawa W, Inoue H, Terui K, Ogino T,
Igarashi R, Takeda K, Akira S, Enosawa S, Furukawa H, Todo S, Ozaki M*.
Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy
in liver-specific STAT3-deficient mice.
J Hepatol.
2005 Nov;43(5):799-807.
- Teshigawara K, Ogawa W*, Mori T, Matsuki Y, Watanabe E, Hiramatsu R, Inoue H, Miyake K, Sakaue H, Kasuga M. Role of Krüppel-like factor
15 in PEPCK gene expression in the liver.
Biochem Biophys Res Commun.
2005 Feb 18;327(3):920-6.
- Hashimoto N, Kido Y*, Uchida T, Matsuda T, Suzuki K, Inoue H,
Matsumoto M, Ogawa W, Maeda S, Fujihara H, Ueta Y, Uchiyama Y, Akimoto
K, Ohno S, Noda T, Kasuga M. PKClambda regulates glucose-induced insulin
secretion through modulation of gene expression in pancreatic beta cells.
J Clin Invest. 2005 Jan;115(1):138-45.
2004
- Inoue H, Ogawa W, Ozaki M, Haga S, Matsumoto
M, Furukawa K, Hashimoto N, Kido Y, Mori T, Sakaue H, Teshigawara K, Jin
S, Iguchi H, Hiramatsu R, LeRoith D, Takeda K, Akira S, Kasuga M*. Role
of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate
metabolism in vivo.
Nat Med. 2004 Feb;10(2):168-74.
Epub 2004 Jan 11.
2003
- Haga S, Terui K, Zhang HQ, Enosawa S, Ogawa W, Inoue H,
Okuyama T, Takeda K, Akira S, Ogino T, Irani K, Ozaki M*. Stat3 protects
against Fas-induced liver injury by redox-dependent and -independent mechanisms.
J Clin Invest. 2003 Oct;112(7):989-98.
- Matsumoto M, Ogawa W*, Akimoto K, Inoue H, Miyake
K, Furukawa K, Hayashi Y, Iguchi H, Matsuki Y, Hiramatsu R, Shimano H,
Yamada N, Ohno S, Kasuga M, Noda T. PKClambda in liver mediates insulin-induced
SREBP-1c expression and determines both hepatic lipid content and overall
insulin sensitivity.
J Clin Invest. 2003 Sep;112(6):935-44.
2002
- Matsumoto M, Ogawa W, Teshigawara K, Inoue H,
Miyake K, Sakaue H, Kasuga M*. Role of the insulin receptor substrate 1
and phosphatidylinositol 3-kinase signaling pathway in insulin-induced
expression of sterol regulatory element binding protein 1c and glucokinase
genes in rat hepatocytes.
Diabetes. 2002 Jun;51(6):1672-80.