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業績一覧

  1. Watanabe H, Inaba Y, Kimura K, Asahara S, Kido Y, Matsumoto M, Motoyama T, Tachibana N, Kaneko S, Kohno M, Inoue H*. Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-induced, Non-alcoholic Fatty Liver Disease.
    J Nutr. in press.
  2. Sakai M, Tsujimura T, Yagi T, Yano H, Mitsushima M, Unoki-Kubota H, Kaburagi Y, Inoue H, Kido Y, Kasuga M, Matsumoto M. The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch.
    Nat Commun. in press.
  3. Morimoto M, Lee EY, Zhang X, Inaba Y, Inoue H, Ogawa M, Shirasawa T, Yokosuka O, Miki T. Eicosapentaenoic acid ameliorates hyperglycemia in high-fat diet-sensitive diabetes mice in conjunction with restoration of hypoadiponectinemia. 
    Nutr Diabetes. 2016 Jun 27;6:e213.
  4. Kimura K#, Tanida M#, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H*. Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor.
    Cell Rep. 2016 Mar 15;14(10):2362-74. (# ; contributed equally)
  5. Kobayashi K, Tanaka T, Okada S, Morimoto Y, Matsumura S, Manio MC, Inoue K, Kimura K, Yagi T, Saito Y, Fushiki T, Inoue H, Matsumoto M, Nabeshima Y. Hepatocyte β-Klotho regulates lipid homeostasis but not body weight in mice.
    FASEB J. 2016 Feb;30(2):849-62.
  6. REVIEW; Inoue H. Central insulin-mediated regulation of hepatic glucose production.
    Endocrine J. 2016 Jan:63(1):1-7.
  7. Asahara S, Etoh H, Inoue H, Teruyama K, Shibutani Y, Ihara Y, Kawada Y, Bartolome A, Hashimoto N, Matsuda T, Koyanagi-Kimura M, Kanno A, Hirota Y, Hosooka T, Nagashima K, Nishimura W, Inoue H, Matsumoto M, Higgins MJ, Yasuda K, Inagaki N, Seino S, Kasuga M, Kido Y. Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c.
    Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8332-7.
  8. Matsuda T, Takahashi H, Mieda Y, Shimizu S, Kawamoto T, Matsuura Y, Takai T, Suzuki E, Kanno A, Koyanagi-Kimura M, Asahara S, Bartolome A, Yokoi N, Inoue H, Ogawa W, Seino S, Kido Y. Regulation of Pancreatic β Cell Mass by Cross-Interaction between CCAAT Enhancer Binding Protein β Induced by Endoplasmic Reticulum Stress and AMP-Activated Protein Kinase Activity.
    PLoS One. 2015 Jun 19;10(6):e0130757
  9. Inaba Y, Furutani T, Kimura K, Watanabe H, Haga S, Kido Y, Matsumoto M, Yamamoto Y, Harada K, Kaneko S, Oyadomari S, Ozaki M, Kasuga M, Inoue H*. Gadd34 regulates liver regeneration in hepatic steatosis.
    Hepatology. 2015 Apr;61(4):1343-56.
  10. Tsuneki H, Tokai E, Nakamura Y, Takahashi K, Fujita M, Asaoka T, Kon K, Anzawa Y, Wada T, Takasaki I, Kimura K, Inoue H, Yanagisawa M, Sakurai T, Sasaoka T*. Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice.
    Diabetes. 2015 Feb;64(2):459-70.
  11. Haga S, Ozawa T, Yamada Y, Morita N, Nagashima I, Inoue H, Inaba Y, Noda N, Abe R, Umezawa K, Ozaki M*. p62/SQSTM1 plays a protective role in oxidative injury of steatotic liver in a mouse hepatectomy model. 
    Antioxid Redox Signal. 2014 Dec 20;21(18):2515-30.
  12. REVIEW; Inoue H. Molecular basis of brain-mediated regulation of hepatic glucose metabolism. 
    Diabetol Int. 2014;5:158-164.
  13. Tanaka M, Ikeda K, Suganami T*, Komiya C, Ochi K, Shirakawa I, Hamaguchi M, Nishimura S, Manabe I, Matsuda T, Kimura K, Inoue H, Inagaki Y, Aoe S, Yamasaki S, and Ogawa Y*. Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis.
    Nat Commun. 2014;5:4982.
  14. Harada K, Kakuda Y, Sato Y, Ikeda H, Shimoda S, Yamamoto Y, Inoue H, Ohta H, Kasashima S, Kawashima A, Nakanuma Y.  Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis.
    J Clin Pathol.2014 May;67(5):396-402.
  15. Park JK, Jang H, Hwang S, Kim EJ, Kim DE, Oh KB, Kwon DJ, Koh JT, Kimura K, Inoue H, Jang WG, Lee JW. ER stress-inducible ATF3 suppresses BMP2-induced ALP expression and activation in MC3T3-E1 cells.
    Biochem Biophys Res Commun. 2014 Jan 3;443(1):333-8.
  16. Kimura K, Nakamura Y, Inaba Y, Matsumoto M, Kido Y, Asahara S, Matsuda T, Watanabe H, Maeda A, Inagaki F, Mukai C, Takeda K, Akira S, Ota T, Nakabayashi H, Kaneko S, Kasuga M, Inoue H*. Histidine augments the suppression of hepatic glucose production by central insulin action.
    Diabetes.2013 Jul;62(7):2266-77.
  17. Kimura I, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T, Terasawa K, Kashihara D, Hirano K, Tani T, Takahashi T, Miyauchi S, Shioi G, Inoue H, Tsujimoto G. The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43.
    Nat Commun. 2013;4:1829.
  18. Lee YS, Sasaki T, Kobayashi M, Kikuchi O, Kim HJ, Yokota-Hashimoto H, Shimpuku M, Susanti VY, Ido-Kitamura Y, Kimura K, Inoue H, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Ohya S, Tanaka Y, Kitajima S, Kitamura T. Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice.
    Diabetologia. 2013 Jun;56(5):1383-93.
  19. Asahara S, Shibutani Y, Teruyama K, Inoue HY, Kawada Y, Etoh H, Matsuda T, Kimura-Koyanagi M, Hashimoto N, Sakahara M, Fujimoto W, Takahashi H, Ueda S, Hosooka T, Satoh T, Inoue H, Matsumoto M, Aiba A, Kasuga M, Kido Y. Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin.
    Diabetologia. 2013 May;56(5):1088-97.
  20. Kitade H, Sawamoto K, Nagashimada M, Inoue H, Yamamoto Y, Sai Y, Takamura T, Yamamoto H, Miyamoto KI, Ginsberg HN, Mukaida N, Kaneko S, Ota T. CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status.
    Diabetes. 2012 Jul;61(7):1680-90.
  21. Sakai M, Matsumoto M, Tujimura T, Yongheng C, Noguchi T, Inagaki K, Inoue H, Hosooka T, Takazawa K, Kido Y, Yasuda K, Hiramatsu R, Matsuki Y, Kasuga M. CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis.
    Nat Med. 2012 Mar;18(4):612-7.
  22. REVIEW; Inoue H. Regulation of glucose metabolism by central insulin action.
    Biomedical Reviews. 2011; 22:31-39..
  23. Kimura K, Yamada T, Matusmoto M, Kido Y, Hosooka T, Asahara S, Matsuda T, Ota T, Watanabe H, Sai Y, Miyamoto K, Kaneko S, Kasuga M, Inoue H*. Endoplasmic Reticulum Stress Inhibits STAT3-dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation.
    Diabetes. 2012 Jan;61(1):61-73.
  24. Koyanagi M, Asahara S, Matsuda T, Hashimoto N, Shigeyama Y, Shibutani Y, Kanno A, Fuchita M, Mikami T, Hosooka T, Inoue H, Matsumoto M, Koike M, Uchiyama Y, Noda T, Seino S, Kasuga M, Kido Y. Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC1.
    PLoS One. 2011;6(8):e23238.
  25. Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim JH, Goode J, Igata M, Paz JC, Hogan MF, Singh PK, Goebel N, Vera L, Miller N, Cui J, Jones MR, CHARGE Consortium, GIANT Consortium, Chen YI, Taylor KD, Hsueh WA, Rotter JI, Montminy M. The CREB Coactivator CRTC3 Links Catecholamine Signaling to Energy Balance.
    Nature. 2010 Dec 16; 468(7326):933-9.
  26. Takashima M, Ogawa W, Hayashi K, Inoue H, Kinoshita S, Okamoto Y, Sakaue H, Wataoka Y, Emi A, Senga Y, Matsuki Y, Watanabe E, Hiramatsu R, Kasuga M. Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action.
    Diabetes. 2010 Jul;59(7):1608-15.
  27. Wang Y, Inoue H, Ravnskjaer K, Viste K, Miller N, Liu Y, Hedrick S, Vera L, Montminy M. Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity.
    Proc Natl Acad Sci USA. 2010 Feb 16;107(7):3087-92.
  28. Matsuda T, Kido Y, Asahara SI, Kaisho T, Tanaka T, Hashimoto N, Shigeyama Y, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Hosooka T, Matsumoto M, Inoue H, Uchida T, Koike M, Uchiyama Y, Akira S, Kasuga M. Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice.
    J Clin Invest. 2010 Jan 4;120(1):115-26.
  29. Oka M, Sakaguchi M, Okada T, Nagai H, Ozaki M, Yoshioka T, Inoue H, Mukaida N, Kikkawa U, Nishigori C. Signal transducer and activator of transcription 3 upregulates interleukin-8 expression at the level of transcription in human melanoma cells.
    Exp Dermatol. 2009 Sep 16.
  30. Haga S, Ozaki M, Inoue H, Okamoto Y, Ogawa W, Takeda K, Akira S, Todo S. The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation.
    Hepatology. 2009 Jan;49(1):204-14.
  31. Nakamichi S, Senga Y, Inoue H, Emi A, Matsuki Y, Watanabe E, Hiramatsu R, Ogawa W, Kasuga M. Role of the E3 ubiquitin ligase GRAIL in glucose and lipid metabolism in the liver.
    J Mol Endocrinol. 2009 Feb;42(2):161-9.
  32. Altarejos JY, Conkright MD, Goebel N, Inoue H, Xie X, Arias CM, Sawchenko PE, Montminy M. The CREB Coactivator TORC1 is Required for Energy Balance and Fertility.
    Nat Med. 2008 Oct;14(10):1112-7.
  33. Hosooka T, Noguchi T, Kotani K, Nakamura T, Sakaue H, Inoue H, Ogawa W, Tobimatsu K, Takazawa K, Sakai M, Matsuki Y, Hiramatsu R, Yasuda T, Lazar MA, Yamanashi Y, Kasuga M. Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation.
    Nat Med. 2008 Feb;14(2):188-93.
  34. Zhang HQ, Haga S, Fukai M, Oikawa Y, Inoue H, Ogawa W, Kano A, Maruyama A, Fu XY, Todo S, Enosawa S, Ozaki M. Identification of de novo STAT3 target gene in liver regeneration.
    Hepatol Res. 2008 Apr;38(4):374-84.
  35. Okamoto Y, Ogawa W, Nishizawa A, Inoue H, Teshigawara K, Kinoshita S, Matsuki Y, Watanabe E, Hiramatsu R, Sakaue H, Noda T, Kasuga M. Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1.
    Diabetes. 2007 Apr;56(4):1000-9.
  36. Inoue H, Ogawa W, Asakawa A, Okamoto Y, Nishizawa A, Matsumoto M, Teshigawara K, Matsuki Y, Watanabe E, Hiramatsu R, Notohara K, Katayose K, Okamura H, Kahn CR, Noda T, Takeda K, Akira S, Inui A, Kasuga M. Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.
    Cell Metab. 2006 Apr;3(4):267-75.
  37. Haga S, Ogawa W, Inoue H, Terui K, Ogino T, Igarashi R, Takeda K, Akira S, Enosawa S, Furukawa H, Todo S, Ozaki M. Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy in liver-specific STAT3-deficient mice.
    J Hepatol. 2005 Nov;43(5):799-807.
  38. Teshigawara K, Ogawa W, Mori T, Matsuki Y, Watanabe E, Hiramatsu R, Inoue H, Miyake K, Sakaue H, Kasuga M. Role of Krüppel-like factor 15 in PEPCK gene expression in the liver.
    Biochem Biophys Res Commun. 2005 Feb 18;327(3):920-6.
  39. Hashimoto N, Kido Y, Uchida T, Matsuda T, Suzuki K, Inoue H, Matsumoto M, Ogawa W, Maeda S, Fujihara H, Ueta Y, Uchiyama Y, Akimoto K, Ohno S, Noda T, Kasuga M. PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells.
    J Clin Invest. 2005 Jan;115(1):138-45.
  40. Inoue H, Ogawa W, Ozaki M, Haga S, Matsumoto M, Furukawa K, Hashimoto N, Kido Y, Mori T, Sakaue H, Teshigawara K, Jin S, Iguchi H, Hiramatsu R, LeRoith D, Takeda K, Akira S, Kasuga M. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo.
    Nat Med. 2004 Feb;10(2):168-74. Epub 2004 Jan 11.
  41. Haga S, Terui K, Zhang HQ, Enosawa S, Ogawa W, Inoue H, Okuyama T, Takeda K, Akira S, Ogino T, Irani K, Ozaki M. Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms.
    J Clin Invest. 2003 Oct;112(7):989-98.
  42. Matsumoto M, Ogawa W, Akimoto K, Inoue H, Miyake K, Furukawa K, Hayashi Y, Iguchi H, Matsuki Y, Hiramatsu R, Shimano H, Yamada N, Ohno S, Kasuga M, Noda T. PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity.
    J Clin Invest. 2003 Sep;112(6):935-44.
  43. Matsumoto M, Ogawa W, Teshigawara K, Inoue H, Miyake K, Sakaue H, Kasuga M. Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes.
    Diabetes. 2002 Jun;51(6):1672-80.
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